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Literature summary for 3.4.24.56 extracted from

  • Zuo, X.; Jia, J.
    Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease (2009), Brain Res., 1249, 1-8.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
IDE genotyping, expression of promoter constructs in Hela cells and SH-SY5Y cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information IDE genotyping identification of polymorphisms, three polymorphisms occur in IDE promoter: -1002T/G (rs3758505), -179T/C (rs4646953) and -51C/T (rs4646954). The -1002T and -51C alleles are overrepresented in 357 sporadic Alzheimer disease patients when compared to those in 331 healthy individuals. Furthermore, -1002T/G and -51C/T are in strong linkage disequilibrium and they construct a relatively risky -1002T/-51C and a relatively protective -1002G/-51T Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Chinese Han populations
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Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
Homo sapiens
-
neuron central nervous system Homo sapiens
-

Synonyms

Synonyms Comment Organism
IDE
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Homo sapiens
insulin degrading enzyme
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Homo sapiens

General Information

General Information Comment Organism
physiological function IDE is involved in amyloid beta degradation. Cerebral accumulation of amyloid beta protein is believed to play a central role in the pathogenesis of Alzheimer's disease. Therefore the gene encoding for insulin degrading enzyme is one of the candidate genes risky for Alzheimer's disease Homo sapiens