Cloned (Comment) | Organism |
---|---|
IDE genotyping, expression of promoter constructs in Hela cells and SH-SY5Y cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | IDE genotyping identification of polymorphisms, three polymorphisms occur in IDE promoter: -1002T/G (rs3758505), -179T/C (rs4646953) and -51C/T (rs4646954). The -1002T and -51C alleles are overrepresented in 357 sporadic Alzheimer disease patients when compared to those in 331 healthy individuals. Furthermore, -1002T/G and -51C/T are in strong linkage disequilibrium and they construct a relatively risky -1002T/-51C and a relatively protective -1002G/-51T | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
Chinese Han populations | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | - |
Homo sapiens | - |
neuron | central nervous system | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
IDE | - |
Homo sapiens |
insulin degrading enzyme | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | IDE is involved in amyloid beta degradation. Cerebral accumulation of amyloid beta protein is believed to play a central role in the pathogenesis of Alzheimer's disease. Therefore the gene encoding for insulin degrading enzyme is one of the candidate genes risky for Alzheimer's disease | Homo sapiens |