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Literature summary for 3.4.24.56 extracted from

  • Bora, R.P.; Prabhakar, R.
    Elucidation of interactions of Alzheimer amyloid beta peptides (Abeta40 and Abeta42) with insulin degrading enzyme: a molecular dynamics study (2010), Biochemistry, 49, 3947-3956.
    View publication on PubMed
Search for more literature for 3.4.24.56

Crystallization (Commentary)

Crystallization (Comment) Organism
analysis of the crystal structure of IDE active site, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on, zinc metallopeptidase, simulated structures of the Zn2+ metal center, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid beta40 + H2O Homo sapiens Abeta40, an Alzheimer amyloid beta peptide amyloid beta40 peptide fragments
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 ?
amyloid beta42 + H2O Homo sapiens Abeta42, an Alzheimer amyloid beta peptide amyloid beta42 peptide fragments
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Organism

Organism UniProt Comment Textmining
Homo sapiens P14735
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta40 + H2O Abeta40, an Alzheimer amyloid beta peptide Homo sapiens amyloid beta40 peptide fragments
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amyloid beta40 + H2O an Alzheimer amyloid beta peptide Homo sapiens amyloid beta40 peptide fragments
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 ?
amyloid beta42 + H2O Abeta42, an Alzheimer amyloid beta peptide Homo sapiens amyloid beta42 peptide fragments
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 ?
amyloid beta42 + H2O an Alzheimer amyloid beta peptide Homo sapiens amyloid beta42 peptide fragments
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 ?
additional information active site structure of IDE, overview. Interactions of the two full-length Alzheimer amyloid beta peptides, Abeta40 and Abeta42, with the fully active form of IDE through unrestrained, all-atom molecular dynamics simulations, using free and small fragment-bound, Asp1-Glu3 and Lys16-Asp23 of Abeta40 and Asp1-Glu3 and Lys16-Glu22 of Abeta42, mutated forms of IDE and NMR structures of the full-length Abeta40 and Abeta42, overview. In comparison to Abeta40, Abeta42 is more flexible and interacts through a smaller number, 17-22, of hydrogen bonds in the catalytic chamber of IDE. Both the substrates adopt more beta-sheet character in the IDE environment. Hydrogen bonding interactions between IDE and substrates amyloidbeta40 and amyloidbeta42, overview Homo sapiens ?
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Synonyms

Synonyms Comment Organism
IDE
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 Homo sapiens
insulin degrading enzyme
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 Homo sapiens

General Information

General Information Comment Organism
malfunction IDE catalyzes the degradation of the monomeric forms of Alzheimer amyloid beta peptides, which is critical for preventing the progression of Alzheimer's disease, overview Homo sapiens