Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Somatostatin | somatostatin binding to IDE brings about a concentration-dependent structural change of the secondary and tertiary structure of the enzyme, revealing two possible binding sites. The higher affinity binding site disappears upon inactivation of IDE by ethylenediaminetetraacetic acid, which chelates the catalytic Zn2+ ion | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | the activation of IDE disappears upon inactivation by EDTA, which chelates the catalytic Zn2+ ion | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.2 | - |
Dabcyl-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Glu(EDANS)-NH2 | pH 7.3, 37°C, presence of 0.04 mM somatostatin | Homo sapiens | |
2.3 | - |
Dabcyl-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Glu(EDANS)-NH2 | pH 7.3, 37°C | Homo sapiens | |
2.5 | - |
amyloid beta1-40 | pH 7.3, 37°C | Homo sapiens | |
7.5 | - |
Somatostatin | pH 7.3, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta1-40 + H2O | - |
Homo sapiens | ? | - |
? | |
Dabcyl-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Glu(EDANS)-NH2 + H2O | fluorogenic derivative of amyloid beta containing residues 10-25 | Homo sapiens | ? | - |
? | |
somatostatin + H2O | cleavage at Phe6-Phe7 bond | Homo sapiens | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.38 | - |
Somatostatin | pH 7.3, 37°C | Homo sapiens | |
8 | - |
amyloid beta1-40 | pH 7.3, 37°C | Homo sapiens | |
61 | - |
Dabcyl-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Glu(EDANS)-NH2 | pH 7.3, 37°C, presence of 0.04 mM somatostatin | Homo sapiens | |
62.7 | - |
Dabcyl-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Glu(EDANS)-NH2 | pH 7.3, 37°C | Homo sapiens |