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Literature summary for 3.4.24.56 extracted from

  • Jee, S.; Hwang, D.; Seo, S.; Kim, Y.; Kim, C.; Kim, B.; Shim, S.; Lee, S.; Sin, J.; Bae, C.; Lee, B.; Jang, M.; Kim, M.; Yim, S.; Jang, I.; Cho, J.; Chae, K.
    Microarray analysis of insulin-regulated gene expression in the liver: the use of transgenic mice co-expressing insulin-siRNA and human IDE as an animal model (2007), Int. J. Mol. Med., 20, 829-835.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of the enzyme in transgenic mice under control of the H1 CMV promoter Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information human enzyme co-expression with specific insulin siRNA in H1/siRNAinsulin-CMV/hIDE transgenic mice, TG9385, using a chromosome integrated dual-recombinant expression system, in lung, brain, liver, kidney, heart, and intestine, with significantly increased enzyme level and activity in the liver, the transgenic mice show impaired glucose tolerance and reduced serum insulin levels compared to wild-type mice, down-regulation of gene transcripts in the liver of H1/siRNAinsulin-CMV/hIDE mice, gene ontology, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens regulation of enzyme expression in the liver, overview ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver regulation of enzyme expression, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information regulation of enzyme expression in the liver, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
IDE
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Homo sapiens
Insulin-degrading enzyme
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Homo sapiens