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Literature summary for 3.4.24.56 extracted from

  • Hwang, D.Y.; Seo, S.; Kim, Y.; Kim, C.; Shim, S.; Jee, S.; Lee, S.; Sin, J.; Cho, J.; Kang, B.; Jang, I.; Cho, J.
    Significant change in insulin production, glucose tolerance and ER stress signaling in transgenic mice coexpressing insulin-siRNA and human IDE (2007), Int. J. Mol. Med., 19, 65-73.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of the enzyme in transgenic mice under control of the H1 CMV promoter Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of transgenic mice, termed H1/siRNAinsulin-CMV/hIDE transgenic mice, TG9385, co-expressing specific insulin siRNA sequences and the human insulin degrading enzyme, hIDE, gene resulting in changes in the proteins in the endoplasmic reticulum stress signal pathway and a diabetes-like phenotype with impaired glucose tolerance and lower serum insulin levels compared to the wild-type mice, expression pattern in muscle, lung, brain, liver, kidney, heart, and intestine, tissue-specific regulation, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin + H2O Homo sapiens degradation, tissue-specific regulation, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
heart
-
Homo sapiens
-
intestine
-
Homo sapiens
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
lung
-
Homo sapiens
-
additional information tissue expression pattern in wild-type mice, tissue-specific regulation, overview Homo sapiens
-
muscle
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin + H2O degradation Homo sapiens ?
-
?
insulin + H2O degradation, tissue-specific regulation, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
IDE
-
Homo sapiens
Insulin-degrading enzyme
-
Homo sapiens