Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
56000 | - |
x * 113000, native enzyme, x * 56000, isolated C-terminal domain IDE-C, 1 * 60000, isolated N-terminal domain IDE-N, SDS-PAGE | Homo sapiens |
60000 | - |
x * 113000, native enzyme, x * 56000, isolated C-terminal domain IDE-C, 1 * 60000, isolated N-terminal domain IDE-N, SDS-PAGE | Homo sapiens |
113000 | - |
x * 113000, native enzyme, x * 56000, isolated C-terminal domain IDE-C, 1 * 60000, isolated N-terminal domain IDE-N, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Subunits | Comment | Organism |
---|---|---|
? | x * 113000, native enzyme, x * 56000, isolated C-terminal domain IDE-C, 1 * 60000, isolated N-terminal domain IDE-N, SDS-PAGE | Homo sapiens |
More | enzyme may be subdivided into roughly equal sized domains IDE-C and IDE-N by limited proteolysis. Separation and analysis of domains show that IDE-N is a monomer and IDE-C serves to oligomerize IDE-N. IDE-C alone does not have catalytic activity, IDE-N alone has 2% of wild-type activity. By complexing IDE-C with IDE-N, activity can be restored to 30% of wild-type | Homo sapiens |