Application | Comment | Organism |
---|---|---|
medicine | stimulation of enzyme activity can provide a useful therapeutic approach in treatment of diseases caused by amyloidosis, like Alzheimer's disease, type2 non-insulin-dependent diabetes and the spongiform encephalopathies such as Creutzfeldt-Jakob disease | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cDNA cloned and expressed | Drosophila melanogaster |
expressed in bacteria | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00002 | - |
Insulin | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Drosophila melanogaster | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Rattus norvegicus | 5829 | - |
peroxisome | - |
Drosophila melanogaster | 5777 | - |
peroxisome | - |
Homo sapiens | 5777 | - |
peroxisome | - |
Rattus norvegicus | 5777 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | contains zinc, essential for its proteolytic activity | Homo sapiens | |
Zn2+ | zinc metallomeptidase | Drosophila melanogaster | |
Zn2+ | zinc metallomeptidase | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
110000 | - |
3 * 110000, SDS-PAGE | Homo sapiens |
300000 | - |
gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
fruit fly | - |
Homo sapiens | - |
human | - |
Rattus norvegicus | - |
rat | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amylin + H2O | - |
Homo sapiens | ? | - |
? | |
atrial natriuretic peptide + H2O | - |
Homo sapiens | ? | - |
? | |
beta-amyloid protein + H2O | - |
Homo sapiens | ? | - |
? | |
beta-amyloid protein + H2O | - |
Rattus norvegicus | ? | - |
? | |
beta-endorphin + H2O | - |
Homo sapiens | ? | - |
? | |
calcitonin + H2O | - |
Homo sapiens | ? | - |
? | |
Glucagon + H2O | - |
Homo sapiens | ? | - |
? | |
haemoglobin + H2O | damaged haemoglobin oxidatively degraded | Homo sapiens | ? | - |
? | |
insulin + H2O | - |
Drosophila melanogaster | ? | - |
? | |
insulin + H2O | - |
Homo sapiens | ? | - |
? | |
insulin + H2O | - |
Rattus norvegicus | ? | - |
? | |
Lysozyme + H2O | degradation of oxidatively damaged lysozyme | Homo sapiens | ? | - |
? | |
additional information | does not act on glucagon-like peptide 1, nerve growth factor, somatostatin, bradykinin, vasopressin, platelet-derived growth factor, and vasoactive intestinal peptide, proinsulin, epidermal growth factor and IGF-I bind to the enzyme but are not efficiently degraded | Homo sapiens | ? | - |
? | |
transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
trimer | 3 * 110000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ADE | - |
Drosophila melanogaster |
ADE | - |
Homo sapiens |
ADE | - |
Rattus norvegicus |
amyloid degrading enzyme | - |
Drosophila melanogaster |
amyloid degrading enzyme | - |
Homo sapiens |
amyloid degrading enzyme | - |
Rattus norvegicus |
gamma-endorphin-generating enzyme | - |
Homo sapiens |
IDE | - |
Drosophila melanogaster |
IDE | - |
Homo sapiens |
IDE | - |
Rattus norvegicus |
insulin degrading enzyme | - |
Drosophila melanogaster |
Insulin protease | - |
Rattus norvegicus |
Insulin-degrading enzyme | - |
Homo sapiens |
Insulin-degrading enzyme | - |
Rattus norvegicus |
Insulinase | - |
Homo sapiens |