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Literature summary for 3.4.24.56 extracted from
- Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development (2003), J. Biol. Chem., 278, 49789-49794.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| amyloid beta-peptide 1-40 | - |
Rattus norvegicus | |
| beta-endorphin | - |
Rattus norvegicus |  |
| bradykinin | - |
Rattus norvegicus | |
| dynorphin A-17 | - |
Rattus norvegicus | |
| dynorphin B-13 | - |
Rattus norvegicus | |
| dynorphin B-9 | 2.5fold increase in amyloid beta peptide hydrolysis | Rattus norvegicus | |
| Insulin B chain | - |
Rattus norvegicus | |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | IDE represents a target for the development of a new class of drugs for the treatment of Alzheimer's disease that lowers amyloid beta-peptide levels by increasing ist rate of catabolism | Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinant enzyme produced in Sf9 cells | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dynorphin B-9 | inhibitory with insulin as substrate | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc metallopeptidase | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid beta peptide 1-40 + H2O | Rattus norvegicus | physiolgical substrate | ? | - |
? | |
| insulin + H2O | Rattus norvegicus | physiolgical substrate | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
rat | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-amino-benzoyl-GGFLRKAGQ-ethylenediamine-2,4-dinitrophenyl + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 2-amino-benzoyl-GGFLRKHGQ-ethylenediamine-2,4-dinitrophenyl + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 2-amino-benzoyl-GGFLRKMGQ-ethylenediamine-2,4-dinitrophenyl + H2O | - |
Rattus norvegicus | ? | - |
? | |
| amyloid beta peptide + H2O | - |
Rattus norvegicus | ? | - |
? | |
| amyloid beta peptide 1-40 + H2O | physiolgical substrate | Rattus norvegicus | ? | - |
? | |
| beta-endorphin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| bradykinin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| dynorphin A-17 + H2O | - |
Rattus norvegicus | ? | - |
? | |
| dynorphin B-13 + H2O | - |
Rattus norvegicus | ? | - |
? | |
| dynorphin B-9 + H2O | - |
Rattus norvegicus | ? | - |
? | |
| insulin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| insulin + H2O | physiolgical substrate | Rattus norvegicus | ? | - |
? | |
| Insulin B-chain + H2O | - |
Rattus norvegicus | ? | - |
? | |
| additional information | gamma-endorphin, Leu-Arg, and Leu-enkephalin are not significantly cleaved | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IDE | - |
Rattus norvegicus |
| Insulin-degrading enzyme | - |
Rattus norvegicus |
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