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Literature summary for 3.4.24.56 extracted from
- Degradation of amylin by insulin-degrading enzyme (2000), J. Biol. Chem., 275, 36621-36625.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the Alzheimer's beta-amyloid peptide is degraded by the enzyme | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Rattus norvegicus |  |
| adrenocorticotropic hormone | competitive inhibition of amylin degradation | Rattus norvegicus | |
| amylin | excess amylin inhibits amylin degradation, competitive inhibition | Rattus norvegicus | |
| Aprotinin | 22.4% inhibition | Rattus norvegicus | |
| atrialnatriuretic peptide | competitive inhibition of amylin degradation | Rattus norvegicus | |
| bacitracin | - |
Rattus norvegicus | |
| EDTA | 21% inhibition; 35.7% inhibition | Rattus norvegicus | |
| glucagon | competitive inhibition of amylin degradation | Rattus norvegicus | |
| Insulin | inhibits amylin degradation, excess insulin inhibits insulin degradation | Rattus norvegicus | |
| additional information | pepstatin-A, leupeptin, and calpains are ineffective as inhibitors, no competitive inhibition with EGF or insulin C-peptide | Rattus norvegicus | |
| N-ethylmaleimide | - |
Rattus norvegicus | |
| PMSF | 14.4% inhibition | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 110000 | - |
SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
rat, Sprague-Dawley | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amylin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| beta-amyloid peptide + H2O | - |
Rattus norvegicus | ? | - |
? | |
| insulin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| additional information | EGF and insulin C-peptide are no substrates | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IDE | - |
Rattus norvegicus |
| Insulin-degrading enzyme | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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