Literature summary for 3.4.24.56 extracted from

Camberos, M.C.; Perez, A.A.; Udrisar, D.P.; Wanderley, M.I.; Cresto, J.C.
ATP inhibits insulin-degrading enzyme activity (2001), Exp. Biol. Med., 226, 334-341.

Search for more literature for 3.4.24.56

Inhibitors

Inhibitors	Comment	Organism	Structure
adenosine 5'-diphosphate	74% inhibition	Rattus norvegicus
adenosine 5'-O-(3thiotriphosphate)	36% inhibition	Rattus norvegicus
ATP	-	Rattus norvegicus
beta-gamma-methyleneadenosine 5'-triphosphate	65% inhibition	Rattus norvegicus
diphosphate	46% inhibition	Rattus norvegicus
guanosine 5'-triphosphate	38% inhibition	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.000058	-	Insulin	pH 7.4, 37°C	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	addition increases insulin degradation	Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
110000	-	SDS-PAGE	Rattus norvegicus
170000	-	gel filtration	Rattus norvegicus
300000	-	gel filtration	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Wistar strain	-
Rattus norvegicus	-	rat, Wistar	-
Rattus norvegicus Wistar	-	Wistar strain	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
Insulin-degrading enzyme	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000045	-	ATP	pH 7.4, 37°C, 3.0 mM ATP	Rattus norvegicus
0.000056	-	ATP	pH 7.4, 37°C, 0.3 mM ATP	Rattus norvegicus
0.00015	-	ATP	pH 7.4, 37°C, allosteric inhibition	Rattus norvegicus

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Release 2023.1 (January 2023)