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Literature summary for 3.4.24.56 extracted from

  • Burghen, G.A.; Kitabchi, A.E.; Brush, J.S.
    Characterization of a rat liver protease with specificity for insulin (1972), Endocrinology, 91, 633-642.
    View publication on PubMed
Search for more literature for 3.4.24.56

Activating Compound

Activating Compound Comment Organism Structure
glutathione stimulates Rattus norvegicus
mercaptoethanol stimulates Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
NEM
-
 Rattus norvegicus
p-hydroxymercuribenzoate
-
 Rattus norvegicus
Phenformin
-
 Rattus norvegicus
Tolbutamide
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0001
-
 Insulin
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
 rat, gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin + H2O Rattus norvegicus major route of insulin catabolism in body ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Insulin + H2O
-
 Rattus norvegicus Hydrolyzed insulin
-
 ?
insulin + H2O major route of insulin catabolism in body Rattus norvegicus ?
-
 ?
additional information human growth hormone is not appreciably degraded Rattus norvegicus ?
-
 ?
Proinsulin + H2O 15fold greater rate of insulin destruction over that for proinsulin Rattus norvegicus Hydrolyzed proinsulin
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
-
 Rattus norvegicus