Cloned (Comment) | Organism |
---|---|
- |
Drosophila melanogaster |
- |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Drosophila melanogaster | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Rattus norvegicus | 5829 | - |
peroxisome | cloned cDNAs of insulin degrading enzyme (human, rat and Drosophila melanogaster) reveal a deduced classical peroxisomal targeting sequence A/SKL at their carboxyl termini, this may account for the peroxisomal location of the enzyme | Drosophila melanogaster | 5777 | - |
peroxisome | cloned cDNAs of insulin degrading enzyme (human, rat and Drosophila melanogaster) reveal a deduced classical peroxisomal targeting sequence A/SKL at their carboxyl termini, this may account for the peroxisomal location of the enzyme | Homo sapiens | 5777 | - |
peroxisome | cloned cDNAs of insulin degrading enzyme (human, rat and Drosophila melanogaster) reveal a deduced classical peroxisomal targeting sequence A/SKL at their carboxyl termini, this may account for the peroxisomal location of the enzyme | Rattus norvegicus | 5777 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
insulin + H2O | Drosophila melanogaster | insulin degrading enzyme is unlikely to be the relevant enzyme for endosomal proteolysis of internalized insulin in liver parenchyma | ? | - |
? | |
insulin + H2O | Homo sapiens | insulin degrading enzyme is unlikely to be the relevant enzyme for endosomal proteolysis of internalized insulin in liver parenchyma | ? | - |
? | |
insulin + H2O | Rattus norvegicus | insulin degrading enzyme is unlikely to be the relevant enzyme for endosomal proteolysis of internalized insulin in liver parenchyma | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Insulin + H2O | - |
Drosophila melanogaster | Hydrolyzed insulin | - |
? | |
Insulin + H2O | - |
Homo sapiens | Hydrolyzed insulin | - |
? | |
Insulin + H2O | - |
Rattus norvegicus | Hydrolyzed insulin | - |
? | |
insulin + H2O | insulin degrading enzyme is unlikely to be the relevant enzyme for endosomal proteolysis of internalized insulin in liver parenchyma | Drosophila melanogaster | ? | - |
? | |
insulin + H2O | insulin degrading enzyme is unlikely to be the relevant enzyme for endosomal proteolysis of internalized insulin in liver parenchyma | Homo sapiens | ? | - |
? | |
insulin + H2O | insulin degrading enzyme is unlikely to be the relevant enzyme for endosomal proteolysis of internalized insulin in liver parenchyma | Rattus norvegicus | ? | - |
? |