Literature summary for 3.4.24.46 extracted from

Grams, F.; Huber, R.; Kress, L.F.; Moroder, L.; Bode, W.
Activation of snake venom metalloproteinases by a cysteine switch-like mechanism (1993), FEBS Lett., 335, 76-80.

Search for more literature for 3.4.24.46

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	activation of inactive adamalysin II zymogen by cystein-switch-like mechanism	Crotalus adamanteus

Inhibitors

Inhibitors	Comment	Organism	Structure
Acetyl-Trp-Cys-Gly-Pro-NH2	-	Crotalus adamanteus
cysteine	-	Crotalus adamanteus
GSH	-	Crotalus adamanteus
Lys-Pro-Arg-Cys-Gly-Val-NH2	-	Crotalus adamanteus
Lys-Thr-Phe-Thr-Ser-Cys	-	Crotalus adamanteus
Pro-Lys-Met-Cys-Gly-Val-NH2	strong	Crotalus adamanteus
Pro-Lys-Met-D-Cys-Gly-Val-NH2	less effective than Pro-Lys-Met-Cys-Gly-Val-NH2	Crotalus adamanteus
Pro-Lys-Met-Ser-Gly-Val-NH2	weak	Crotalus adamanteus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	zinc containing metalloproteinase	Crotalus adamanteus

Organism

Organism	UniProt	Comment	Textmining
Crotalus adamanteus	-	Eastern diamondback rattlesnake	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
venom	-	Crotalus adamanteus	-

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	assay at	Crotalus adamanteus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
additional information	-	alkaline assay conditions	Crotalus adamanteus

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Release 2023.1 (January 2023)