Cloned (Comment) | Organism |
---|---|
- |
Crotalus atrox |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | - |
Crotalus atrox | |
EDTA | - |
Crotalus atrox | |
Human plasma alpha2-macroglobulin | - |
Crotalus atrox | |
additional information | synthetic peptide inhibitors with N-[1-(R,S)-3-dicarboxypropyl] moiety | Crotalus atrox | |
Pyroglutamate peptides | e.g. pyro-Glu-Asn-Trp or pyro-Glu-Glu-Trp | Crotalus atrox | |
Synthetic peptide inhibitors with N-[1-(R,S)-carboxypentyl] moiety | - |
Crotalus atrox |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | can be directly exchanged for zinc by dialysis without loss of specificity or activity | Crotalus atrox | |
Zn2+ | zinc metalloproteinase | Crotalus atrox | |
Zn2+ | 1 mol zinc/mol enzyme | Crotalus atrox |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25700 | - |
1 * 25700, Crotalus atrox, SDS-PAGE | Crotalus atrox |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Basement membranes surrounding capillaries + H2O | Crotalus atrox | contributes to hemorrhagic property by weakening capillary walls, together with atrolysins B and C member of the class P-I hemorrhagic toxins | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crotalus atrox | - |
Western diamondback rattlesnake | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | no glycoprotein | Crotalus atrox |
Purification (Comment) | Organism |
---|---|
from lyophilized crude venom | Crotalus atrox |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Crotalus atrox | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Basement membrane preparation + H2O | - |
Crotalus atrox | Soluble peptides | - |
? | |
Basement membranes surrounding capillaries + H2O | contributes to hemorrhagic property by weakening capillary walls, together with atrolysins B and C member of the class P-I hemorrhagic toxins | Crotalus atrox | ? | - |
? | |
Collagen type IV alphaI(IV) chains + H2O | basement membrane component, cleavage at Ala219-Gln220 | Crotalus atrox | ? | - |
? | |
Collagen type IV alphaII(IV) chain + H2O | basement membrane component, cleavage at Thr228-Leu229 | Crotalus atrox | ? | - |
? | |
Fibrinogen + H2O | - |
Crotalus atrox | Hydrolyzed fibrinogen | non-clotting products | ? | |
Fibronectin + H2O | - |
Crotalus atrox | Hydrolyzed fibronectin | lower MW fragments | ? | |
Gelatin of collagen type I + H2O | - |
Crotalus atrox | ? | - |
? | |
Gelatin of collagen type II + H2O | - |
Crotalus atrox | ? | - |
? | |
Gelatin of collagen type III + H2O | - |
Crotalus atrox | ? | - |
? | |
Gelatin of collagen type V + H2O | - |
Crotalus atrox | ? | - |
? | |
Human alpha2-macroglobulin + H2O | cleavage at Val689-Met690 and Gly693-His694 | Crotalus atrox | ? | - |
? | |
Laminin + H2O | - |
Crotalus atrox | ? | - |
? | |
Laminin/nidogen complex + H2O | cleavage at positions 322, 336, 351, 840 and 953 | Crotalus atrox | ? | - |
? | |
additional information | no hydrolysis of fibrin | Crotalus atrox | ? | - |
? | |
additional information | no hydrolysis of native collagens | Crotalus atrox | ? | - |
? | |
additional information | substrate digestion patterns differ from those of atrolysins A and C | Crotalus atrox | ? | - |
? | |
Nidogen + H2O | basement membrane component, cleavage at positions 75, 296, 336, 402, 478, 625, 702 and 920 | Crotalus atrox | ? | - |
? | |
Oxidized insulin B-chain + H2O | - |
Crotalus atrox | Hydrolyzed oxidized insulin B-chain | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 25700, Crotalus atrox, SDS-PAGE | Crotalus atrox |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
pI: 5.6 | Crotalus atrox |