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Literature summary for 3.4.24.41 extracted from
- Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom (1988), Biol. Chem. Hoppe-Seyler, 369, 121-129.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Crotalus atrox |  |
| EDTA | - |
Crotalus atrox | |
| Hemorrhagic toxin inhibitor from Crotalus atrox | - |
Crotalus atrox |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc metalloproteinase, 1 mol zinc/mol enzyme | Crotalus atrox | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 24000 | - |
1 * 24000, Crotalus atrox, SDS-PAGE | Crotalus atrox |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Crotalus atrox | - |
Western diamondback rattlesnake | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Crotalus atrox | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Basement membrane preparation + H2O | poor substrate: component band a | Crotalus atrox | Soluble peptides | - |
? | |
| Laminin + H2O | basement membrane component, poor substrate | Crotalus atrox | ? | - |
? | |
| additional information | no hydrolysis of fibrin | Crotalus atrox | ? | - |
? | |
| additional information | no hydrolysis of fibronectin | Crotalus atrox | ? | - |
? | |
| Nidogen + H2O | basement membrane component | Crotalus atrox | ? | - |
? | |
| Oxidized insulin B-chain + H2O | cleavage sites: His5-Leu6, His10-Leu11, Ala14-Leu15, Tyr16-Leu17 (atrolysin A and C cleave the same bonds) and Gly23-Phe24 (atrolysin C, EC 3.4.24.42 cleaves the same bond) | Crotalus atrox | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 24000, Crotalus atrox, SDS-PAGE | Crotalus atrox |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Crotalus atrox |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0267 | - |
oxidized insulin B-chain | Gly23-Phe24 bond | Crotalus atrox | |
| 0.0317 | - |
oxidized insulin B-chain | His5-Leu6 bond | Crotalus atrox | |
| 0.132 | - |
oxidized insulin B-chain | His10-Leu11 bond | Crotalus atrox | |
| 0.803 | - |
oxidized insulin B-chain | Ala14-Leu15 bond | Crotalus atrox | |
| 1.02 | - |
oxidized insulin B-chain | Tyr16-Leu17 bond | Crotalus atrox |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
basic pI | Crotalus atrox |
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Release 2023.1 (January 2023)
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