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Literature summary for 3.4.24.36 extracted from

  • Lynn, M.A.; Kindrachuk, J.; Marr, A.K.; Jenssen, H.; Pante, N.; Elliott, M.R.; Napper, S.; Hancock, R.E.; McMaster, W.R.
    Effect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survival (2011), PLoS Negl. Trop. Dis., 5, e1141.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.36

Inhibitors

Inhibitors Comment Organism Structure
additional information the cathelicidin bovine myeloid antimicrobial peptide 28, BMAP-28, has broad antimicrobial activities and confers protection in animal models of bacterial infection or sepsis. BMAP-28 isomers,i.e. the D-amino acid form D-BMAP-28 and the retro-inverso form RI-BMAP-28, are resistant against GP63 protease activity and act as anti-leishmanial agents against the promastigote and amastigote intracellular Leishmania major lifecycle stages, overview Leishmania major

Organism

Organism UniProt Comment Textmining
Leishmania major
-
-
-
Leishmania major MHOM/IL/80/Friedlin
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote
-
 Leishmania major
-
promastigote
-
 Leishmania major
-

Synonyms

Synonyms Comment Organism
GP63 surface metalloprotease
-
 Leishmania major

General Information

General Information Comment Organism
malfunction a leishmanolysin knockout strain of Leishmania major Seidman strain lacks the GP63 surface metalloprotease Leishmania major
additional information the cathelicidin bovine myeloid antimicrobial peptide 28, BMAP-28, has broad antimicrobial activities and confers protection in animal models of bacterial infection or sepsis. BMAP-28 isomers,i.e. the D-amino acid form D-BMAP-28 and the retro-inverso form RI-BMAP-28, are resistant against GP63 protease activity and act as anti-leishmanial agents against the promastigote and amastigote intracellular Leishmania major lifecycle stages, overview Leishmania major