Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | GP63 is located in punctuated structures along the cell periphery in infected macrophages, with partial colocalization with the lipid raft marker cholera toxin B | Leishmania sp. | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein tyrosine phosphatase PTP1B + H2O | Leishmania sp. | activation and posttranslationally modification of host enzymes in infected macrophages. The PTP1B cleavage fragments are enzymatically active. The mechanism underlying PTP modulation involves the proteolytic activity of the Leishmania surface protease GP63 | ? | - |
? | |
protein tyrosine phosphatase SHP-1 + H2O | Leishmania sp. | activation and posttranslationally modification of host enzymes in infected macrophages. The SHP-1 cleavage fragments are enzymatically active | ? | - |
? | |
protein tyrosine phosphatase TCPTP + H2O | Leishmania sp. | activation and posttranslationally modification of host enzymes in infected macrophages. The TCPTP cleavage fragments are enzymatically active | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania sp. | - |
propagated in B10R murine MO cell line | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein tyrosine phosphatase PTP1B + H2O | activation and posttranslationally modification of host enzymes in infected macrophages. The PTP1B cleavage fragments are enzymatically active. The mechanism underlying PTP modulation involves the proteolytic activity of the Leishmania surface protease GP63 | Leishmania sp. | ? | - |
? | |
protein tyrosine phosphatase PTP1B + H2O | activation and posttranslationally modification of host enzymes in infected macrophages | Leishmania sp. | ? | - |
? | |
protein tyrosine phosphatase SHP-1 + H2O | activation and posttranslationally modification of host enzymes in infected macrophages. The SHP-1 cleavage fragments are enzymatically active | Leishmania sp. | ? | - |
? | |
protein tyrosine phosphatase SHP-1 + H2O | activation and posttranslationally modification of host enzymes in infected macrophages | Leishmania sp. | ? | - |
? | |
protein tyrosine phosphatase TCPTP + H2O | activation and posttranslationally modification of host enzymes in infected macrophages. The TCPTP cleavage fragments are enzymatically active | Leishmania sp. | ? | - |
? | |
protein tyrosine phosphatase TCPTP + H2O | activation and posttranslationally modification of host enzymes in infected macrophages | Leishmania sp. | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gp63 | - |
Leishmania sp. |
surface protease GP63 | - |
Leishmania sp. |
General Information | Comment | Organism |
---|---|---|
physiological function | GP63 is a key Leishmania virulence factor. Leishmania GP63 alters the profile of protein tyrosine phosphatases associated with JAK-2 at the host cell plasma membrane | Leishmania sp. |