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Literature summary for 3.4.24.36 extracted from

  • Kulkarni, M.M.; McMaster, W.R.; Kamysz, E.; Kamysz, W.; Engman, D.M.; McGwire, B.S.
    The major surface-metalloprotease of the parasitic protozoan, Leishmania, protects against antimicrobial peptide-induced apoptotic killing (2006), Mol. Microbiol., 62, 1484-1497.
    View publication on PubMed
Search for more literature for 3.4.24.36

Protein Variants

Protein Variants Comment Organism
additional information leishmanolysin-knock out mutants show a substantially higher sensitivity to inhibitors and their antileishmanial activity, such as members of the alpha- and phi-defensins, magainins and cathelicidins, pexiganan-treatment of knock out mutants induces disruption of surface-membrane permeability and expression of features of apoptosis including smaller cell size, loss of mitochondrial membrane potential, exposure of surface phosphatidyl serine as well as induction of caspase 3/7 activity, phenotype and pexiganan cleavage products generated by leishmanolysin degradation, overview Leishmania major

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Leishmania major 9986
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Leishmania major the major surface-metalloprotease is a virulence factor which contributes to a variety of functions including evasion of complement-mediated parasite-killing and host intramacrophage survival, the protozoan enzyme protects the parasite against antimicrobial peptide-induced apoptotic killing by the host cell, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Leishmania major
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the major surface-metalloprotease is a virulence factor which contributes to a variety of functions including evasion of complement-mediated parasite-killing and host intramacrophage survival, the protozoan enzyme protects the parasite against antimicrobial peptide-induced apoptotic killing by the host cell, overview Leishmania major ?
-
 ?

Synonyms

Synonyms Comment Organism
major surface-metalloprotease
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 Leishmania major