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Literature summary for 3.4.24.36 extracted from
- The crystal structure of the Leishmania major surface proteinase leishmanolysin (gp63) (1998), Structure, 6, 1035-1046.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enzyme plays a key role during infection of humans with Leishmania parasites, inhibitors may aid the development of drugs | Leishmania major |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| monoclinic crystals, space group C2 with a : 107.2 A, b : 90.6 A, c : 70.6 A, and tetragonal crystals, space group P4(1)2(1)2(1), a : b : 63.6 A, c : 251.4 A | Leishmania major |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | membrane-bound | Leishmania major | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc proteinase | Leishmania major |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania major | P08148 | LRC-L119 | - |
| Leishmania major LRC-L119 | P08148 | LRC-L119 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Leishmania major |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| gp63 | - |
Leishmania major |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9 | - |
Leishmania major |
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