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Literature summary for 3.4.24.36 extracted from

  • Corradin, S.; Ransijn, A.; Corradin, G.; Roggero, M.A.; Schmitz, A.A.; Schneider, P.; Mauel, J.; Vergeres, G.
    MARCKS-related protein (MRP) is a substrate for the Leishmania major surface protease leishmanolysin (gp63) (1999), J. Biol. Chem., 274, 25411-25418.
    View publication on PubMed
Search for more literature for 3.4.24.36

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli JM109(DE3) Leishmania major

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Leishmania major
additional information degradation of MARCKS-related protein MRP is inhibited by protein kinase C-dependent phosphorylation of MRP Leishmania major

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
63000
-
 SDS-PAGE Leishmania major

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Leishmania major Leishmania promastigotes reside in the midgut of the phlebotomine sand fly and invade host macrophages during a sand fly bite, infection may result in leishmanolysin-dependent hydrolysis of MRP, a major protein kinase C substrate in macrophages ?
-
 ?
additional information Leishmania major LV39 Leishmania promastigotes reside in the midgut of the phlebotomine sand fly and invade host macrophages during a sand fly bite, infection may result in leishmanolysin-dependent hydrolysis of MRP, a major protein kinase C substrate in macrophages ?
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania major
-
 LV39
-
Leishmania major LV39
-
 LV39
-

Purification (Commentary)

Purification (Comment) Organism
-
 Leishmania major

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
MARCKS-related protein MRP + H2O
-
 Leishmania major ?
-
 ?
MARCKS-related protein MRP + H2O
-
 Leishmania major LV39 ?
-
 ?
additional information Leishmania promastigotes reside in the midgut of the phlebotomine sand fly and invade host macrophages during a sand fly bite, infection may result in leishmanolysin-dependent hydrolysis of MRP, a major protein kinase C substrate in macrophages Leishmania major ?
-
 ?
additional information Leishmania promastigotes reside in the midgut of the phlebotomine sand fly and invade host macrophages during a sand fly bite, infection may result in leishmanolysin-dependent hydrolysis of MRP, a major protein kinase C substrate in macrophages Leishmania major LV39 ?
-
 ?
myristoylated alanine-rich C kinase substrate MARCKS + H2O
-
 Leishmania major ?
-
 ?
myristoylated alanine-rich C kinase substrate MARCKS + H2O
-
 Leishmania major LV39 ?
-
 ?

Synonyms

Synonyms Comment Organism
gp63
-
 Leishmania major
Leishmania surface metalloprotease
-
 Leishmania major

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 9
-
 Leishmania major

pH Range

pH Minimum pH Maximum Comment Organism
5 11
-
 Leishmania major