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Literature summary for 3.4.24.36 extracted from

  • Chaudhuri, G.; Chaudhuri, M.; Pan, A.; Chang, K.P.
    Surface acid proteinase (gp63) of Leishmania mexicana. A metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages (1989), J. Biol. Chem., 264, 7483-7489.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline inactivation by dialysis against 1,10-phenanthroline, reactivation of apoenzyme by Zn2+, partially by Cu2+, Co2+, Cd2+ or Ni2+, not by Hg2+, Ca2+, Fe2+, Pb2+, Ba2+, Sn2+, Mg2+, Mn2+, Fe3+ or Ag+; strong, 1 mM, Zn2+ reverses, bovine serum albumin as substrate Leishmania amazonensis
2,2'-bipyridyl strong, Zn2+ reverses, bovine serum albumin as substrate Leishmania amazonensis
2-mercaptoethylamine Zn2+ reverses, bovine serum albumin as substrate Leishmania amazonensis
8-hydroxyquinoline Zn2+ reverses, bovine serum albumin as substrate Leishmania amazonensis
EDTA strong, Zn2+ reverses, bovine serum albumin as substrate Leishmania amazonensis
EGTA strong, Zn2+ reverses, bovine serum albumin as substrate Leishmania amazonensis
thioglycolic acid Zn2+ reverses, bovine serum albumin as substrate Leishmania amazonensis

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface major surface protein Leishmania amazonensis 9986
-
cell surface major surface protein Leishmania mexicana pifanoi 9986
-
membrane
-
Leishmania amazonensis 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc zinc containing metalloproteinase Leishmania amazonensis
Zinc zinc containing metalloproteinase Leishmania mexicana pifanoi
Zinc amino acid sequence between 161-173 and 304-308 shows strong homology to zinc-binding sites with the histidine ligands and the glutamate ligand of other metalloproteinases Leishmania amazonensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Leishmania amazonensis protects parasite membrane from cytosolic damage during their survival, differentiation and multiplication in the phagolysosomes of macrophages ?
-
?
additional information Leishmania mexicana pifanoi protects parasite membrane from cytosolic damage during their survival, differentiation and multiplication in the phagolysosomes of macrophages ?
-
?
additional information Leishmania amazonensis LV78 protects parasite membrane from cytosolic damage during their survival, differentiation and multiplication in the phagolysosomes of macrophages ?
-
?

Organism

Organism UniProt Comment Textmining
Leishmania amazonensis
-
LV78
-
Leishmania amazonensis LV78
-
LV78
-
Leishmania mexicana pifanoi
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Leishmania amazonensis
glycoprotein
-
Leishmania mexicana pifanoi

Purification (Commentary)

Purification (Comment) Organism
promastigotes, monoclonal affinity purification Leishmania amazonensis

Source Tissue

Source Tissue Comment Organism Textmining
amastigote enzymes from promastigotes and amastigotes are not identical but immunologically related Leishmania amazonensis
-
amastigote enzymes from promastigotes and amastigotes are not identical but immunologically related Leishmania mexicana pifanoi
-
amastigote axenic amastigotes from Leishmania mexicana pifanoi grown under macrophage-free conditions Leishmania mexicana pifanoi
-
promastigote enzymes from promastigotes and amastigotes are not identical but immunologically related Leishmania amazonensis
-
promastigote enzymes from promastigotes and amastigotes are not identical but immunologically related Leishmania mexicana pifanoi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Bovine serum albumin + H2O radioiodinated Leishmania amazonensis ?
-
?
Bovine serum albumin + H2O radioiodinated Leishmania mexicana pifanoi ?
-
?
Bovine serum albumin + H2O radioiodinated Leishmania amazonensis LV78 ?
-
?
Fibrinogen + H2O
-
Leishmania amazonensis ?
-
?
Fibrinogen + H2O
-
Leishmania amazonensis LV78 ?
-
?
Hemoglobin + H2O
-
Leishmania amazonensis ?
-
?
Hemoglobin + H2O
-
Leishmania mexicana pifanoi ?
-
?
Hemoglobin + H2O
-
Leishmania amazonensis LV78 ?
-
?
additional information non-specific endopeptidase Leishmania amazonensis ?
-
?
additional information protects parasite membrane from cytosolic damage during their survival, differentiation and multiplication in the phagolysosomes of macrophages Leishmania amazonensis ?
-
?
additional information protects parasite membrane from cytosolic damage during their survival, differentiation and multiplication in the phagolysosomes of macrophages Leishmania mexicana pifanoi ?
-
?
additional information non-specific endopeptidase Leishmania amazonensis LV78 ?
-
?
additional information protects parasite membrane from cytosolic damage during their survival, differentiation and multiplication in the phagolysosomes of macrophages Leishmania amazonensis LV78 ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Leishmania amazonensis
37
-
assay at Leishmania mexicana pifanoi
60
-
-
Leishmania amazonensis
60
-
-
Leishmania mexicana pifanoi

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4
-
promastigote enzyme Leishmania amazonensis