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Literature summary for 3.4.24.35 extracted from

  • Kakimoto, K.; Takai, S.; Murano, M.; Ishida, K.; Yoda, Y.; Inoue, T.; Jin, D.; Umegaki, E.; Higuchi, K.
    Significance of chymase-dependent matrix metalloproteinase-9 activation on indomethacin-induced small intestinal damages in rats (2010), J. Pharmacol. Exp. Ther., 332, 684-689.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
chymase chymase converts promatrix metalloproteinase-9 to matrix metalloproteinase-9 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
small intestine
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-9
-
Rattus norvegicus
MMP-9
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus in the extract from the small intestine 24 h after indomethacin administration, the MMP-9 activation is significantly attenuated by 10 mg/kg 2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl] thiazole-4-carboxylic acid down
Rattus norvegicus MMP-9 activity is significantly increased to 5.0 and 6.1times of the normal intestinal value 12 and 24 h after indomethacin administration, respectively up