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Literature summary for 3.4.24.35 extracted from

  • Liu, W.; Hendren, J.; Qin, X.J.; Shen, J.; Liu, K.J.
    Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia (2009), J. Neurochem., 108, 811-820.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.35

Inhibitors

Inhibitors Comment Organism Structure
BB1101 MMP inhibitor Rattus norvegicus
GM6001 MMP inhibitor, complete inhibition at 0.025 mM Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
microvessel
-
 Rattus norvegicus
-
telencephalon
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
 Rattus norvegicus ?
-
 ?
occludin + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-9
-
 Rattus norvegicus
MMP-9
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus normobaric hyperoxia inhibits MMP-9-mediated occludin degradation in the ischemic hemispheric microvessels down
Rattus norvegicus ischemia and reperfusion induce an upregulation of MMP-9 in the ischemic hemispheric microvessels up

General Information

General Information Comment Organism
physiological function MMP-9- mediated occludin degradation represents an important mechanism for blood brain barrier disruption in ischemic stroke Rattus norvegicus