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Literature summary for 3.4.24.35 extracted from

  • Ardi, V.C.; Van den Steen, P.E.; Opdenakker, G.; Schweighofer, B.; Deryugina, E.I.; Quigley, J.P.
    Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway (2009), J. Biol. Chem., 284, 25854-25866.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information the presence of an intact active site and hemopexin domain are required for full angiogenesis-inducing activity of the MMP-9 enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Tissue inhibitor of metalloproteinase-1
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
82000
-
2 * 82000, active MMP-9, SDS-PAGE Homo sapiens
92000
-
2 * 92000, proMMP-9, SDS-PAGE Homo sapiens
200000
-
the molecular weight of proMMP-9 is about 200000 Da, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
gelatin-Sepharose column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen + H2O
-
Homo sapiens ?
-
?
Gelatin + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 82000, active MMP-9, SDS-PAGE Homo sapiens
homodimer 2 * 92000, proMMP-9, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-9
-
Homo sapiens
MMP-9
-
Homo sapiens

General Information

General Information Comment Organism
physiological function MMP-9 catalytically induces angiogenesis via a basic fibroblast growth factor-2/fibroblast growth factor receptor-2 pathway. The enhanced angiogenesis catalyzed by neutrophil MMP-9 evokes also a localized, low threshold level vascular endothelial growth factor/vascular endothelial growth factor receptor-2 pathway, likely functioning in the formation and/or stabilization of blood vessels Homo sapiens