Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the presence of an intact active site and hemopexin domain are required for full angiogenesis-inducing activity of the MMP-9 enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Tissue inhibitor of metalloproteinase-1 | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
82000 | - |
2 * 82000, active MMP-9, SDS-PAGE | Homo sapiens |
92000 | - |
2 * 92000, proMMP-9, SDS-PAGE | Homo sapiens |
200000 | - |
the molecular weight of proMMP-9 is about 200000 Da, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
gelatin-Sepharose column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Collagen + H2O | - |
Homo sapiens | ? | - |
? | |
Gelatin + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 82000, active MMP-9, SDS-PAGE | Homo sapiens |
homodimer | 2 * 92000, proMMP-9, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-9 | - |
Homo sapiens |
MMP-9 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | MMP-9 catalytically induces angiogenesis via a basic fibroblast growth factor-2/fibroblast growth factor receptor-2 pathway. The enhanced angiogenesis catalyzed by neutrophil MMP-9 evokes also a localized, low threshold level vascular endothelial growth factor/vascular endothelial growth factor receptor-2 pathway, likely functioning in the formation and/or stabilization of blood vessels | Homo sapiens |