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Literature summary for 3.4.24.35 extracted from

  • Heilpern, A.J.; Wertheim, W.; He, J.; Perides, G.; Bronson, R.T.; Hu, L.T.
    Matrix metalloproteinase 9 plays a key role in lyme arthritis but not in dissemination of Borrelia burgdorferi (2009), Infect. Immun., 77, 2643-2649.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.35

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Mus musculus
-
 ?
-
 ?
Gelatin + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen type I + H2O
-
 Mus musculus ?
-
 ?
collagen type II + H2O
-
 Mus musculus ?
-
 ?
collagen type IV + H2O
-
 Mus musculus ?
-
 ?
collagen type V + H2O
-
 Mus musculus ?
-
 ?
collagen type VII + H2O
-
 Mus musculus ?
-
 ?
Elastin + H2O
-
 Mus musculus ?
-
 ?
Gelatin + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
gelatinase B
-
 Mus musculus
Matrix metalloproteinase 9
-
 Mus musculus
MMP-9
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus Borrelia burgdorferi induces the host protease, matrix metalloproteinase 9, the induction of MMP-9 may allow the organism to disseminate and produce local tissue destruction up

General Information

General Information Comment Organism
physiological function matrix metalloproteinase 9 plays a key role in lyme arthritis but not in dissemination of Borrelia burgdorferi. MMP-9 cleavage of type I collagen results in increased monocyte chemoattraction, MMP-9 plays an important role in regulating inflammation in Lyme arthritis, potentially through the cleavage of collagen type I Mus musculus