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Literature summary for 3.4.24.35 extracted from

  • Grierson, C.; Miller, D.; Lapan, P.; Brady, J.
    Utility of combining MMP-9 ELISA and MMP-9 activity assay data to monitor plasma enzyme specific-activity (2010), Anal. Biochem., 404, 232-234.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
4-aminophenylmercuric acetate APMA activation of MMP-9 affects tissue inhibitor of metalloproteinase-1 binding to the enzyme resulting in the loss of natural enzyme inhibition Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Tissue inhibitor of metalloproteinase-1 exogenous tissue inhibitor of metalloproteinase-1 has a greater inhibitory effect on endogenously active MMP-9 than on 4-aminophenylmercuric acetate-activated MMP-9 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
65000
-
4-aminophenylmercuric acetate produces not only the 82000 Da active enzyme but also a C-terminal truncated form of approximately 65000 Da with activity comparable to that of the 82000 Da form Homo sapiens
82000
-
active enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase 9
-
Homo sapiens
MMP-9
-
Homo sapiens