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Literature summary for 3.4.24.35 extracted from

  • Lee, Y.M.; Lee, J.J.; Shen, M.Y.; Hsiao, G.; Sheu, J.R.
    Inhibitory mechanisms of activated matrix metalloproteinase-9 on platelet activation (2006), Eur. J. Pharmacol., 537, 52-58.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
4-aminophenylmercuric acetate proteolytically activates the enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secreted enzyme Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
86000
-
x * 92000, pro-MMP9, SDS-PAGE, x * 86000, activated MMP-9, SDS-PAGE Homo sapiens
92000
-
x * 92000, pro-MMP9, SDS-PAGE, x * 86000, activated MMP-9, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Collagen + H2O Homo sapiens MMP-9 inhibits collagen-induced platelet aggregation ?
-
?
additional information Homo sapiens activated MMP-9 initially induces conformational changes in platelet membranes, affecting membrane fluidity, and hydroxyl radical formation and inhibits the Na+/H+ pump, both leading to inhibition of platelet aggregation, the latter via reduced Ca2+ mobilization, overview. MMP-9 also inhibits arachidonic acid, ADP, and U46619 inducetion of platelet aggregation, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification 4-aminophenylmercuric acetate proteolytically activates the enzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet MMP-9 secretion Homo sapiens
-
commercial preparation purified from neutrophil granulocytes Homo sapiens
-
granulocyte neutrophil, commercial preparation Homo sapiens
-
neutrophil
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen + H2O
-
Homo sapiens ?
-
?
Collagen + H2O MMP-9 inhibits collagen-induced platelet aggregation Homo sapiens ?
-
?
additional information activated MMP-9 initially induces conformational changes in platelet membranes, affecting membrane fluidity, and hydroxyl radical formation and inhibits the Na+/H+ pump, both leading to inhibition of platelet aggregation, the latter via reduced Ca2+ mobilization, overview. MMP-9 also inhibits arachidonic acid, ADP, and U46619 inducetion of platelet aggregation, overview Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 92000, pro-MMP9, SDS-PAGE, x * 86000, activated MMP-9, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-9
-
Homo sapiens
MMP-9
-
Homo sapiens