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Literature summary for 3.4.24.35 extracted from

  • Jeyabalan, A.; Novak, J.; Doty, K.D.; Matthews, J.; Fisher, M.C.; Kerchner, L.J.; Conrad, K.P.
    Vascular matrix metalloproteinase-9 mediates the inhibition of myogenic reactivity in small arteries isolated from rats after short-term administration of relaxin (2007), Endocrinology, 148, 189-197.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information MMP-9 is induced in small renal arteries by recombinant human relaxin, up-regulation of 70% Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
cyclic CTT peptide a gelatinase inhibitor peptide Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
92000
-
x * 92000, pro-MMP-9, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gelatin + H2O Rattus norvegicus
-
?
-
?
additional information Rattus norvegicus myogenic reactivity, inhibited in small renal arteries isolated from nonpregnant rats treated with recombinant human relaxin, is completely restored by incubation with MMP-9, MMP-9 rather than MMP-2 plays a central role in the vasodilatory effect of short-term relaxin administration, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Long-Evans female rats
-

Source Tissue

Source Tissue Comment Organism Textmining
renal artery immunohistochemic analysis Rattus norvegicus
-
vascular smooth muscle
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
MMP-9 activity in relaxin-treated and untreated renal artery, overview Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
Rattus norvegicus ?
-
?
Gelatin + H2O gelatin zymography Rattus norvegicus ?
-
?
additional information myogenic reactivity, inhibited in small renal arteries isolated from nonpregnant rats treated with recombinant human relaxin, is completely restored by incubation with MMP-9, MMP-9 rather than MMP-2 plays a central role in the vasodilatory effect of short-term relaxin administration, overview Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
? x * 92000, pro-MMP-9, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-9
-
Rattus norvegicus
MMP-9
-
Rattus norvegicus