Literature summary for 3.4.24.35 extracted from

Di Girolamo, N.; Indoh, I.; Jackson, N.; Wakefield, D.; McNeil, H.P.; Yan, W.; Geczy, C.; Arm, J.P.; Tedla, N.
Human mast cell-derived gelatinase B (matrix metalloproteinase-9) is regulated by inflammatory cytokines: role in cell migration (2006), J. Immunol., 177, 2638-2650.

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Application

Application	Comment	Organism
medicine	abundant expression of enzyme by synovial tissue mast cells in patients with rheumatoid arthritis but not in normal control	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
mast cell	treatment of blood-derived mast cells with TNF-alpha significantly increases expression of enzyme mRNA and upregulates enzyme activity. TNF-alpha also increases the invasiveness of mast cells across Matrigel-coated membranes. INF-gamma is inhibitory to enzyme mRNA and protein expression	Homo sapiens	-

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Release 2023.1 (January 2023)