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Literature summary for 3.4.24.35 extracted from

  • Olson, M.W.; Bernardo, M.M.; Pietila, M.; Gervasi, D.C.; Toth, M.; Kotra, L.P.; Massova, I.; Mobashery, S.; Fridman, R.
    Characterization of the monomeric and dimeric forms of latent and active matrix metalloproteinase-9. Differential rates for activation by stromelysin 1 (2000), J. Biol. Chem., 275, 2661-2668.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
tissue inhibitor of metalloproteinase TIMP-1
-
Homo sapiens
tissue inhibitor of metalloproteinase TIMP-2
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000013
-
stromelysin1 pH 7.5, 37°C, monomeric form Homo sapiens
0.000025
-
stromelysin1 pH 7.5, 37°C, dimeric form Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
92000
-
monomeric form, SDS-PAGE Homo sapiens
210000
-
dimeric form, SDS-PAGE Homo sapiens
225000
-
Western blot Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens associated with degradation of the extracellular matrix in normal and pathological conditions ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P45452 human
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumaryl-4yl)acetylPLGLA2pr(2,4-dinitrophenol)-AR-NH2 + H2O
-
Homo sapiens ?
-
?
additional information associated with degradation of the extracellular matrix in normal and pathological conditions Homo sapiens ?
-
?
stromelysin 1 + H2O
-
Homo sapiens ?
-
?
stromelysin1 + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
dimer
-
Homo sapiens
monomer
-
Homo sapiens

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-9
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.00041
-
stromelysin 1 pH 7.5, 37°C, dimeric form Homo sapiens
0.0019
-
stromelysin 1 pH 7.5, 37°C, monomeric form Homo sapiens
0.04 1.97 (7-methoxycoumaryl-4yl)acetylPLGLA2pr(2,4-dinitrophenol)-AR-NH2 pH 7.5, 37°C, dimeric form Homo sapiens
2.72
-
(7-methoxycoumaryl-4yl)acetylPLGLA2pr(2,4-dinitrophenol)-AR-NH2 pH 7.5, 37°C, monomeric form Homo sapiens
3 6 (7-methoxycoumaryl-4yl)acetylPLGLA2pr(2,4-dinitrophenol)-AR-NH2 pH 7.5, 37°C, monomeric form Homo sapiens
8.67
-
(7-methoxycoumaryl-4yl)acetylPLGLA2pr(2,4-dinitrophenol)-AR-NH2 pH 7.5, 37°C, dimeric form Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000713
-
TIMP-1 pH 7.5, 37°C, dimeric form Homo sapiens
0.00000817
-
TIMP-1 pH 7.5, 37°C, monomeric form Homo sapiens
0.0000259
-
TIMP-2 pH 7.5, 37°C, monomeric form Homo sapiens
0.0000361
-
TIMP-2 pH 7.5, 37°C, dimeric form Homo sapiens