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Literature summary for 3.4.24.34 extracted from

  • Han, J.; Lee, E.; Moon, E.; Ryu, J.; Choi, J.; Kim, H.
    Matrix metalloproteinase-8 is a novel pathogenetic factor in focal cerebral ischemia (2016), Mol. Neurobiol., 53, 231-239 .
    View publication on PubMed
Search for more literature for 3.4.24.34

Cloned(Commentary)

Cloned (Comment) Organism
gene MMP8, quantitative real-time PCR enzyme expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information enzyme silencing by MMP8-specific shRNA Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
(3R)-1,2,3,4-tetrahydro-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-3-isoquinolinecarboxamide i.e. matrix metalloproteinase-8 Inhibitor I or M8I, administration of the MMP8 inhibitor immediately after reperfusion reduces brain damage Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Mus musculus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a zinc-dependent endopeptidase Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus O70138
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain ifMMP8 expression is upregulated in brains with cerebral ischemia Mus musculus
-
microglia
-
 Mus musculus
-
additional information MMP8 expression is upregulated in the activated microglia of M/R-challenged brains Mus musculus
-

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-8
-
 Mus musculus
MMP8
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus MMP8 expression is upregulated in the activated microglia of M/R-challenged brains up

General Information

General Information Comment Organism
malfunction intracerebroventricular microinjection of MMP8-specific shRNA lentivirus reduces the extent of ischemia-induced brain damage, as assessed by infarct volume, neurological score, microglial activation, and TNF-alpha expression. Administration of an MMP8 inhibitor (M8I) immediately after reperfusion reduced brain damage Mus musculus
physiological function neutrophil collagenase matrix metalloproteinase-8 (MMP8) belongs to the MMPs that have important roles in various inflammation-related disorders. MMP8 is a neuroinflammatory mediator in activated microglia by regulating TNF-alpha productivity. Pathogenetic role of MMP8 Mus musculus