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Literature summary for 3.4.24.34 extracted from

  • Atkinson, S.J.; Varisco, B.M.; Sandquist, M.; Daly, M.N.; Klingbeil, L.; Kuethe, J.W.; Midura, E.F.; Harmon, K.; Opaka, A.; Lahni, P.; Piraino, G.; Hake, P.; Zingarelli, B.; Mortenson, J.E.; Wynn, J.L.; Wong, H.R.
    Matrix metalloproteinase-8 augments bacterial clearance in a juvenile sepsis model (2016), Mol. Med., 22, 455-463 .
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information generation of MMP-8 knockout mutant mice. In contrast to septic adult mice, genetic ablation of MMP8 increases mortality following bacterial peritonitis in juvenile mice. This increase in mortality is associated with rexadduced bacterial clearance and reduced NET efficiency. Juvenile MMP8 null mice have greater mortality and higher bacterial burden than wild-type mice. Genetic ablation of MMP8 in juvenile mice increases mortality following sepsis from polymicrobial peritonitis Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
(3R)-N-hydroxy-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carboxamide
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 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus O70138
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-
Mus musculus C57BL/6 O70138
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-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
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 Mus musculus
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neutrophil
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 Mus musculus
-

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-8
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 Mus musculus
MMP-8
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 Mus musculus

General Information

General Information Comment Organism
malfunction juvenile MMP8 null mice have greater mortality and higher bacterial burden than wild-type mice. Leukocyte counts and cytokine concentrations in the peritoneal fluid are increased in the MMP8 null mice relative to the wild-type mice. Peritoneal macrophages from MMP8 null mice have reduced phagocytic capacity compared to wild-type macrophages. There is no quantitative difference in NET formation, but fewer bacteria are adherent to NETs from MMP8 null animals Mus musculus
physiological function matrix metalloproteinase-8 augments bacterial clearance in a juvenile sepsis model. Developmental age influences the role of MMP8 in sepsis, mechanism by which MMP8 influences outcomes in sepsis, analysis of local cytokine response in juvenile wild-type and MMP8 null mice with peritoneal sepsis, overview Mus musculus