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Literature summary for 3.4.24.34 extracted from

  • Daly, M.C.; Atkinson, S.J.; Varisco, B.M.; Klingbeil, L.; Hake, P.; Lahni, P.; Piraino, G.; Wu, D.; Hogan, S.P.; Zingarelli, B.; Wong, H.R.
    Role of matrix metalloproteinase-8 as a mediator of injury in intestinal ischemia and reperfusion (2016), FASEB J., 30, 3453-3460 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.34

Protein Variants

Protein Variants Comment Organism
additional information construction of MMP8-null mice, phenotype of I/R injury mice and non-ischemic mice. Genetic ablation of MMP8 preserves claudin-3 expression Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
(3R)-(+)-[2-(4-methoxybenzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-hydroxamate]
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Mus musculus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a zinc metalloproteinase Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus O70138
-
-
Mus musculus C57BL/6 O70138
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium intestinal Mus musculus
-
ileum
-
 Mus musculus
-
intestine distal ileum, wild-type mice subjected to I/R injury have significantly higher MMP8 serum concentrations compared to sham-treated mice Mus musculus
-
lung
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase 8
-
 Mus musculus
Matrix metalloproteinase-8
-
 Mus musculus
MMP8
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus MMP8 is induced during intestinal injury up

General Information

General Information Comment Organism
malfunction ischemia-reperfusion (I/R) injury leads to increased expression of intestinal and systemic MMP8. Inhibition of MMP8 prevents intestinal barrier dysfunction following I/R injury. MMP8-null mice have reduced intestinal permeability to FD-40 compared with wild-type mice. Wild-type mice treated with MMP8 inhibitor also have a significant reduction of intestinal neutrophil infiltration as compared with wild-type mice treated with vehicle. Claudin-3 expression is reduced after I/R injury, relative to the respective sham-treated animals, and this effect is ameliorated by either genetic ablation or pharmacologic inhibition of MMP8. Inhibition of MMP8 decreases neutrophil infiltration in the intestine and lung and prevents intestinal damage, myeloperoxidase activity is reduced, overview Mus musculus
physiological function role of matrix metalloproteinase-8 (MMP8) as a mediator of injury in intestinal ischemia and reperfusion. MMP8 is induced during intestinal injury Mus musculus