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Literature summary for 3.4.24.34 extracted from

  • Schubert-Unkmeir, A.; Konrad, C.; Slanina, H.; Czapek, F.; Hebling, S.; Frosch, M.
    Neisseria meningitidis induces brain microvascular endothelial cell detachment from the matrix and cleavage of occludin: A role for MMP-8 (2010), PLoS Pathog., 6, 1-15.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
MMP-8 inhibitor I in the presence of specific MMP-8 I inhibitor formation of the occludin cleavage product is prevented Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens MP-8 is involved in the proteolytic cleavage of the tight junction protein occludin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell infection of human brain microvascular endothelial cells (HBMEC) with Neisseria meningitidis induces an increase in MMP-8 activity Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MP-8 is involved in the proteolytic cleavage of the tight junction protein occludin Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MMP-8
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction abrogation of MMP-8 activity by specific inhibitors as well as transfection with MMP-8 siRNA abolishes production of the cleavage fragment and occludin remained attached to the cell periphery Homo sapiens
physiological function MMP-8 is involved in the proteolytic cleavage of the tight junction protein occludin, resulting in its disappearance from the cell periphery and cleavage to a lower-sized 50-kDa protein in infected human brain microvascular endothelial cells Homo sapiens