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Literature summary for 3.4.24.27 extracted from

  • Gokhale, N.H.; Bradford, S.; Cowan, J.A.
    Stimulation and oxidative catalytic inactivation of thermolysin by copper.Cys-Gly-His-Lys (2007), J. Biol. Inorg. Chem., 12, 981-987.
    View publication on PubMed
Search for more literature for 3.4.24.27

Activating Compound

Activating Compound Comment Organism Structure
Cu2+-Cys-Gly-His-Lys stimulation at concentration up to 0.01 mM, inhibition at higher concentrations of 0.01-0.1 mM, binding and kinetics, overview Bacillus thermoproteolyticus
Cys-Gly-His-Lys activation Bacillus thermoproteolyticus

Inhibitors

Inhibitors Comment Organism Structure
Cu2+-Cys-Gly-His-Lys stimulation at concentration up to 0.01 mM, inhibition at higher concentrations of 0.01-0.1 mM, binding and kinetics, overview Bacillus thermoproteolyticus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ four ions per enzyme molecule required for stability Bacillus thermoproteolyticus
Zn2+ one ion per enzyme molecule essential for activity, the enzyme contains the HEXXH motif constituting the zinc catalytic site Bacillus thermoproteolyticus

Organism

Organism UniProt Comment Textmining
Bacillus thermoproteolyticus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Bacillus thermoproteolyticus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH + H2O
-
 Bacillus thermoproteolyticus ?
-
 ?

Synonyms

Synonyms Comment Organism
TLN
-
 Bacillus thermoproteolyticus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bacillus thermoproteolyticus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Bacillus thermoproteolyticus