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Literature summary for 3.4.24.27 extracted from

  • Matthews, B.W.; Colman, P.M.; Jansonius, J.N.; Titani, K.; Walsh, K.A.; Neurath, H.
    Structure of thermolysin (1972), Nat. New Biol., 238, 41-43.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ there are two adjacent calcium ions seemingly firmly bound inside the surface of the molecule by chelation to five acidic groups: Asp138, Glu177, Asp185, Glu190 and Asp191, two additional calcium binding sites are at exposed surface regions, one chelated by Asp57 and possibly also by Asp59 and the other chelated by Asp200 Bacillus thermoproteolyticus
Zinc the three zinc ligands are two histidines and glutamic acid Bacillus thermoproteolyticus

Organism

Organism UniProt Comment Textmining
Bacillus thermoproteolyticus
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commercial available thermolysin
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