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Literature summary for 3.4.24.26 extracted from
- Pseudomonas aeruginosa elastase. Development of a new substrate, inhibitors, and an affinity ligand (1980), J. Biol. Chem., 255, 3482-3486.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ClCH2CO-N-hydroxyleucine-Ala-Gly-NH2 | - |
Pseudomonas aeruginosa |  |
| additional information | not: ClCH2CO-N-hydroxyleucine-OCH3 | Pseudomonas aeruginosa | |
| peptides | containing the hydroxamic acid, N-hydroxypeptide and thiol functional groups | Pseudomonas aeruginosa | |
| phosphoramidon | - |
Pseudomonas aeruginosa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.11 | - |
2-Aminobenzoyl-Ala-Gly-Leu-Ala 4-nitrobenzylamide | - |
Pseudomonas aeruginosa | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Pseudomonas aeruginosa | probably responsible for the tissue destruction observed during pulmonary and corneal infections by the pathogen organism Pseudomonas aeruginosa | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Pseudomonas aeruginosa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-Aminobenzoyl-Ala-Gly-Leu-Ala 4-nitrobenzylamide + H2O | - |
Pseudomonas aeruginosa | 2-Aminobenzoyl-Ala-Gly + Leu-Ala 4-nitrobenzylamide | - |
? | |
| benzyloxycarbonyl-Ala-Leu-Ala + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
| furylacryloyl-Gly-Leu-NH2 + H2O | poor substrate | Pseudomonas aeruginosa | furylacryloyl-Gly + Leu-NH2 | - |
? | |
| additional information | probably responsible for the tissue destruction observed during pulmonary and corneal infections by the pathogen organism Pseudomonas aeruginosa | Pseudomonas aeruginosa | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 100 | - |
2-Aminobenzoyl-Ala-Gly-Leu-Ala 4-nitrobenzylamide | - |
Pseudomonas aeruginosa | |
| 1100 | - |
benzyloxycarbonyl-Ala-Leu-Ala | - |
Pseudomonas aeruginosa | |
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