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Literature summary for 3.4.24.24 extracted from

  • Nejima, D.; Zarkouna, Y.; Pujol, P.; Gammoudi, A.; Boussen, H.; Manai, M.
    Clinicopathologic and prognostic significance of gelatinase A in Tunisian colorectal cancer a case-control study (2017), Appl. Immunohistochem. Mol. Morphol., 25, 64-70 .
    View publication on PubMed
Search for more literature for 3.4.24.24

Cloned(Commentary)

Cloned (Comment) Organism
gene MMP2, genotyping in Tunesian population. The levels of MMP-2 mRNA expression in patients containing the CC genotype are much higher compared with cells with the CT genotype. The frequency of the MMP-2 CC genotype is significantly higher in colorectal cancer patients when compared with controls Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for activity Homo sapiens
Zn2+ zinc metalloprotease Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gelatin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P08253 Tunesian population
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell higher intensity of staining of MMP-2 is observed in regions of invasion of the muscularis mucosa compared with superficial portions of the tumor in colorectal cancer Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
gelatinase A
-
 Homo sapiens
matrix metalloproteinase-2
-
 Homo sapiens
MMP-2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens significant progressive increase in total MMP-2 plasma levels with progression from adenomatous polyps through advancing Dukes stages up

General Information

General Information Comment Organism
physiological function matrix metalloproteinase-2 (gelatinase A) is a mediator of cancer metastasis, but it is also thought to be involved in several aspects of cancer development, including cell growth and inflammation. MMP-2 may be associated with colorectal cancer development and invasion in the Tunisian population Homo sapiens