Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted as inactive proenzyme | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08253 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | concanavalin A induces the enzyme activation through membrane type 1 matrix metalloprotease from 72 kDA proenzyme to 62 kDa active enzyme in the non-pigmented ciliary epithelial cells and fibroblast from periodontal ligaments | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | oxytalan fibers | Homo sapiens | - |
fibroblast | from periodontal ligaments | Homo sapiens | - |
non-pigmented ciliary epithelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fibrillin-1 + H2O | from eye oxytalan fibers, degradation in vitro | Homo sapiens | ? | - |
? | |
fibrillin-2 + H2O | from eye oxytalan fibers, degradation in vitro | Homo sapiens | ? | - |
? | |
Gelatin + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-2 | - |
Homo sapiens |
MMP-2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme MMP-2 is considered a major enzyme involved in the turnover of the extracellular matrix. The enzyme is involved in the degradation of fibrillin-1 and fibrillin-2, the degradation patterns differ between the eye and the periodontal ligaments, possibly reflecting the sensitivity of fibrillin-1 and fibrillin-2 of each type of oxytalan fiber against enzyme MMP-2 | Homo sapiens |