Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.24 extracted from

  • Kawagoe, M.; Tsuruga, E.; Oka, K.; Sawa, Y.; Ishikawa, H.
    Matrix metalloproteinase-2 degrades fibrillin-1 and fibrillin-2 of oxytalan fibers in the human eye and periodontal ligaments in vitro (2013), Acta Histochem. Cytochem., 46, 153-159.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted as inactive proenzyme Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gelatin + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P08253
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification concanavalin A induces the enzyme activation through membrane type 1 matrix metalloprotease from 72 kDA proenzyme to 62 kDa active enzyme in the non-pigmented ciliary epithelial cells and fibroblast from periodontal ligaments Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
eye oxytalan fibers Homo sapiens
-
fibroblast from periodontal ligaments Homo sapiens
-
non-pigmented ciliary epithelial cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrillin-1 + H2O from eye oxytalan fibers, degradation in vitro Homo sapiens ?
-
?
fibrillin-2 + H2O from eye oxytalan fibers, degradation in vitro Homo sapiens ?
-
?
Gelatin + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-2
-
Homo sapiens
MMP-2
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

General Information

General Information Comment Organism
physiological function enzyme MMP-2 is considered a major enzyme involved in the turnover of the extracellular matrix. The enzyme is involved in the degradation of fibrillin-1 and fibrillin-2, the degradation patterns differ between the eye and the periodontal ligaments, possibly reflecting the sensitivity of fibrillin-1 and fibrillin-2 of each type of oxytalan fiber against enzyme MMP-2 Homo sapiens