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Literature summary for 3.4.24.24 extracted from
- Collagen-binding domains of gelatinase A and thrombospondin-derived peptides impede endocytic clearance of active gelatinase A and promote HT1080 fibrosarcoma cell invasion (2008), Life Sci., 82, 376-382.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| aminophenylmercuric acetate | - |
Homo sapiens |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of the first, second, and third module, i.e. CBD1, CBD2 and CBD3 polypeptides, and of the fibronectin type-II-like modelues of MMP-2 in Escherichia coli | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | CBD123 decreases active MMP-2 levels in HT-1080 cells, but only marginally the content of pro-MMP-2, overview | Homo sapiens | |
| TIMP-2 | pro-MMP-2-TIMP-2 complexes are endocytosed into HT-1080 cells | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | TSP-1 acts in LRP-mediated clearance of MMP-2, TIMP-2 complexing leads to MMP-2 accumulation in the cells | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant CBD1, CBD2 and CBD3 polypeptides and fibronectin type-II-like modelues of MMP-2 from Escherichia coli, by gelatin affinity chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | recombinant MMP-2 | Homo sapiens | - |
| HT-1080 cell | fibrosarcoma cell | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gelatin + H2O | gelatin zymography | Homo sapiens | ? | - |
? | |
| additional information | TSP-1 acts in LRP-mediated clearance of MMP-2, TIMP-2 complexing leads to MMP-2 accumulation in the cells | Homo sapiens | ? | - |
? | |
| additional information | the enzyme shows strong interaction with TSP-1 and CBD123, surface plasmon resonance analysis, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| gelatinase A | - |
Homo sapiens |
| matrix metalloprotenase-2 | - |
Homo sapiens |
| MMP-2 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
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