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Literature summary for 3.4.24.24 extracted from

  • Zhao, J.X.; Yang, L.P.; Wang, Y.F.; Qin, L.P.; Liu, D.Q.; Bai, C.X.; Nan, X.; Shi, S.S.; Pei, X.J.
    Gelatinolytic activity of matrix metalloproteinase-2 and matrix metalloproteinase-9 in rat brain after implantation of 9L rat glioma cells (2007), Eur. J. Neurol., 14, 510-516.
    View publication on PubMed
Search for more literature for 3.4.24.24

Activating Compound

Activating Compound Comment Organism Structure
additional information implantation of 9L glioma cells into brain increases the expression of MMP-2, overview Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Rattus norvegicus
Zn2+
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
66000
-
 x * 72000, pro-MMP-2, SDS-PAGE, x * 66000, activated MMP-2, SDS-PAGE Rattus norvegicus
72000
-
 x * 72000, pro-MMP-2, SDS-PAGE, x * 66000, activated MMP-2, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gelatin + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Fisher344 rats
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification activation Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain expression analysis in brain after implantation of 9L glioma cells, overview Rattus norvegicus
-
glioma cell high expression level of MMP-2 increasing during growth Rattus norvegicus
-
additional information MMP-2 is increased in tumor cells Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
 Rattus norvegicus ?
-
 ?
Gelatin + H2O gelatin zymography Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 72000, pro-MMP-2, SDS-PAGE, x * 66000, activated MMP-2, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-2
-
 Rattus norvegicus
MMP-2
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus