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Literature summary for 3.4.24.24 extracted from

  • Fridman, R.; Bird, R.E.; Hoyhta, M.; Oelkuct, M.; Komarek, D.; Liang, C.M.; Berman, M.L.; Liotta, L.A.; Stetler-Stevenson, W.G.; Fuerst, T.R.
    Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): characterization of complex and free enzyme (1993), Biochem. J., 289, 411-416.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
Tissue inhibitor of metalloproteinase-2 TIMP-2, not only a potent inhibitor of the activated enzyme but also prevents the generation of low-molecular-mass species and full enzymic activity from the zymogen Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
62000
-
 x * 62000, human, active enzyme, SDS-PAGE under reducing conditions Homo sapiens
72000
-
 x * 72000, human, zymogen, SDS-PAGE under reducing conditions Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
culture medium from HeLa cells co-infected with each of the recombinant Vaccinia viruses and with vTF7-3 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen + H2O
-
 Homo sapiens ?
-
 ?
Gelatin + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 62000, human, active enzyme, SDS-PAGE under reducing conditions Homo sapiens
? x * 72000, human, zymogen, SDS-PAGE under reducing conditions Homo sapiens