Application | Comment | Organism |
---|---|---|
drug development | matrilysin is an ideal biological target to developl inhibitors because it is overexpressed in malignant tumour cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4-phenyl-1,4-dihydropyridine-3,5-diyl)dimethanol | - |
Homo sapiens | |
3,9-di(4-methoxylphenyl)-6,12-diphenyl-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
3,9-di(4-methylphenyl)-6,12-diphenyl-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
3,9-dibenzyl-1,5,7,11-tetrahydroxymethyl-6,12-di(2,3,4-trimethoxylphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane | - |
Homo sapiens | |
3,9-dibenzyl-1,5,7,11-tetrahydroxymethyl-6,12-di(2,4,5-trimethoxylphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane | - |
Homo sapiens | |
3,9-dibenzyl-1,5,7,11-tetrahydroxymethyl-6,12-di(2,4-dimethoxylphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane | - |
Homo sapiens | |
3,9-dibenzyl-1,5,7,11-tetrahydroxymethyl-6,12-di(4-hydroxyphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane | - |
Homo sapiens | |
3,9-dibenzyl-6,12-di(2,3,4-trimethoxylphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
3,9-dibenzyl-6,12-di(2,4,5-trimethoxylphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
3,9-dibenzyl-6,12-di(2,4-dimethoxylphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
3,9-dibenzyl-6,12-di(3,4,5-trimethoxylphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
3,9-dibenzyl-6,12-di(4-hydroxyphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
3,9-dibenzyl-6,12-di(4-methoxylphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
3,9-dibenzyl-6,12-diphenyl-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
3,9-diphenyl-6,12-di(4-fluoridephenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
3,9-diphenyl-6,12-di(4-hydroxyphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
3,9-diphenyl-6,12-di(4-methoxylphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
3,9-diphenyl-6,12-di(4-methylphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
3,9-diphenyl-6,12-diphenyl-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
3.9-diphenyl-6,12-di(3,4,5-trimethoxylphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
6,12-di(2,3,4-trimethoxylphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
6,12-di(2,4,5-trimethoxylphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
6,12-di(2,4-dimethoxylphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
6,12-di(3,4,5-trimethoxylphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
6,12-di(4-hydroxyphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
6,12-di(4-methoxylphenyl)-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
6,12-diphenyl-3,9-diazahexacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate | - |
Homo sapiens | |
Ag-3340 | - |
Homo sapiens | |
diethyl 1-phenoxy-4-(4-propylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate | - |
Homo sapiens | |
diethyl 4-(2-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate | - |
Homo sapiens | |
diethyl 4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | - |
Homo sapiens | |
diethyl 4-(3-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate | - |
Homo sapiens | |
diethyl 4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | - |
Homo sapiens | |
diethyl 4-(4-methylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate | - |
Homo sapiens | |
diethyl 4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | - |
Homo sapiens | |
diethyl 4-(4-nitrophenyl)-1-phenoxy-1,4-dihydropyridine-3,5-dicarboxylate | - |
Homo sapiens | |
diethyl 4-(4-propylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate | - |
Homo sapiens | |
diethyl 4-[4-(5-methoxypentyl)phenyl]-1,4-dihydropyridine-3,5-dicarboxylate | - |
Homo sapiens | |
diethyl 4-[4-(5-methoxypentyl)phenyl]-1-phenoxy-1,4-dihydropyridine-3,5-dicarboxylate | - |
Homo sapiens | |
marimastat | - |
Homo sapiens | |
additional information | design, synthesis and biological evaluation of 3,9-diazatetraasteranes as matrilysin inhibitors, molceular docking and simulations, overview. Common interaction mechanism of 3,9-diazatetraasteranes with the catalytic site of matrilysin | Homo sapiens | |
N-[3-[3,5-bis(hydroxymethyl)-1,4-dihydropyridin-4-yl]phenyl]acetamide | - |
Homo sapiens | |
N-[3-[3,5-bis(hydroxymethyl)-1-phenoxy-1,4-dihydropyridin-4-yl]phenyl]acetamide | - |
Homo sapiens | |
RRS269 | - |
Homo sapiens | |
[4-(2,4-dimethoxyphenyl)-1-phenoxy-1,4-dihydropyridine-3,5-diyl]dimethanol | - |
Homo sapiens | |
[4-(3,4,5-trimethoxyphenyl)-1,4-dihydropyridine-3,5-diyl]dimethanol | - |
Homo sapiens | |
[4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-diyl]dimethanol | - |
Homo sapiens | |
[4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-diyl]dimethanol | - |
Homo sapiens | |
[4-(4-propylphenyl)-1,4-dihydropyridine-3,5-diyl]dimethanol | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09237 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
evolution | matrilysin is a member of the matrix metalloproteinase (MMP) gene family | Homo sapiens |
physiological function | the enzyme is responsible for aggressive malignant phenotypes and poor prognoses implicated in many cancers | Homo sapiens |