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Literature summary for 3.4.24.23 extracted from

  • Ansell, A.; Jerhammar, F.; Ceder, R.; Grafstroem, R.; Grenman, R.; Roberg, K.
    Matrix metalloproteinase-7 and -13 expression associate to cisplatin resistance in head and neck cancer cell lines (2009), Oral Oncol., 45, 866-871.
    View publication on PubMed
Search for more literature for 3.4.24.23

Application

Application Comment Organism
diagnostics MMP-7 is a potential biomarker of intrinsic cisplatin sensitivity, ICS, which cisplatin treatment outcome in cancer therapy for advanced head and neck squamous cell carcinomas, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
fibronectin 1 fibronectin 1, interacts with MMP-7 Homo sapiens
TIMP3 tissue inhibitor of metalloproteinase-3, interacts with MMP-7 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens MMP-7 interacts with insulin-like growth factor binding protein 5, inhibitor of metalloproteinase-3, fibronectin 1, and TFPI ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
salivary duct cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MMP-7 interacts with insulin-like growth factor binding protein 5, inhibitor of metalloproteinase-3, fibronectin 1, and TFPI Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-7
-
 Homo sapiens
MMP-7
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function MMP-7 is a key regulator of cisplatin resistance in cells of head and neck squamous cell carcinomas, overview Homo sapiens