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Literature summary for 3.4.24.23 extracted from
- Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomas (2009), Lab. Invest., 89, 98-105.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | introduction of an Mmp7 knockout mutation into the cis-Apc/Smad4 mutant mouse, a model of invasive colon cancer in which SMAD4-dependent TGF-beta family signaling is inactivated. Lack of MMP7 reduces the number and size of tumors in the cis-Apc/Smad4 mice | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colorectal cancer cell | - |
Mus musculus | - |
| colorectal cancer cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Matrix metalloproteinase 7 | - |
Mus musculus |
| Matrix metalloproteinase 7 | - |
Homo sapiens |
| MMP7 | - |
Mus musculus |
| MMP7 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | expression of MMP7 is increased in human colorectal carcinomas, and correlates with malignant progression, role of MMP7 in colon cancer progression, overview. MMP7 is required for tumor formation, but not for the invasion or fibrosis of the colon cancer | Homo sapiens |
| physiological function | role of MMP7 in colon cancer progression, overview. MMP7 is required for tumor formation, but not for the invasion or fibrosis of the colon cancer whose SMAD4-dependent TGF-beta family signaling is blocked | Mus musculus |
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Release 2023.1 (January 2023)
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