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Literature summary for 3.4.24.23 extracted from

  • Goswami, S.; Angkasekwinai, P.; Shan, M.; Greenlee, K.J.; Barranco, W.T.; Polikepahad, S.; Seryshev, A.; Song, L.Z.; Redding, D.; Singh, B.; Sur, S.; Woodruff, P.; Dong, C.; Corry, D.B.; Kheradmand, F.
    Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma (2009), Nat. Immunol., 10, 496-503.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information allergen-challenged Mmp7-/- mice show less airway hyperreactivity and production of allergic inflammatory cytokines and higher expression of retinal dehydrogenase 1. Inhibition of retinal dehydrogenase 1 restores the asthma phenotype of Mmp7-/- mice and inhibits the responses of lung regulatory T cells, whereas exogenous administration of retinoic acid attenuates the asthma phenotype, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium
-
 Homo sapiens
-
respiratory epithelium cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase 7
-
 Homo sapiens
MMP7
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function epithelial MMP7 is expressed during asthma and is required for the maximum activity of interleukin 25 in promoting the differentiation of T helper type 2 cells. MMP7 coordinates allergic lung inflammation by activating interleukin 25 while simultaneously inhibiting retinoid-dependent development of regulatory T cells Homo sapiens