Literature summary for 3.4.24.23 extracted from

Liu, H.; Zhang, T.; Wu, B.; Huang, J.; Zhou, Y.; Zhu, J.
Chronic exposure to exogenous matrilysin induces chemoresistance and enhances Bcl-2 expression in A549 lung adenocarcinoma cells (2008), Mol. Biol. Rep., 36, 2099-2109.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	chronic exposure to crescenting level of exogenous matrilysin does not significantly alter the growth rates of A-549 cells. A certain range of matrilysin might protect tumor cells from cisplatin-mediated death. The underlying mechanism may be due to the Bcl-2 overexpression and imbalance in the ratio of Bcl-2/Bax	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	recombinant enzyme	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	chronic exposure to crescenting level of exogenous matrilysin does not significantly alter the growth rates of A-549 cells. A certain range of matrilysin might protect tumor cells from cisplatin-mediated death. The underlying mechanism may be due to the Bcl-2 overexpression and imbalance in the ratio of Bcl-2/Bax	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)