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Literature summary for 3.4.24.23 extracted from

  • Gorodeski, G.I.
    Estrogen decrease in tight junctional resistance involves matrix-metalloproteinase-7-mediated remodeling of occludin (2007), Endocrinology, 148, 218-231.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.23

Activating Compound

Activating Compound Comment Organism Structure
additional information estrogen stimulates activation of the pro-MMP-7 intracellularly in the Golgi apparatus and augments secretion of the activated MMP-7 form, steady-state levels of MMP-7 mRNA and protein are not affected by estrogen, monensin, but not tunicamycin and brefeldin-A, blocks estrogen effects, overview, estrogen increases co-immunoreactivity of MMP-7 with synaptosomal-associated protein of 25 kDa in apical membranes, bafilomycin A1 inhibits activation of MMP-7 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information estrogen acidification of the luminal solution tends to alkalinize exocytotic vesicles and may lead to decreased activation of the MMP-7 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted via soluble N-ethylmaleimide sensitive fusion factor attachment protein receptor-facilitated exocytosis of MMP-7 Homo sapiens
-
-
additional information estrogen stimulates activation of the pro-MMP-7 intracellularly and augmented secretion of the activated MMP-7 form, overview Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is regulated involving estrogen, which affects enzyme expression and secretion, mechanism, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09237
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification Pro-MM-7 is proteolytically activated prior to secretion Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
cervix
-
 Homo sapiens
-
epithelial cell vaginal-cervical epithelial cells secrete constitutively MMP-7 into the luminal solution Homo sapiens
-
vagina
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is regulated involving estrogen, which affects enzyme expression and secretion, mechanism, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
matrix-metalloproteinase-7
-
 Homo sapiens
MMP-7
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens