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Literature summary for 3.4.24.23 extracted from

  • Miyamoto, S.; Nakamura, M.; Yano, K.; Ishii, G.; Hasebe, T.; Endoh, Y.; Sangai, T.; Maeda, H.; Shi-Chuang, Z.; Chiba, T.; Ochiai, A.
    Matrix metalloproteinase-7 triggers the matricrine action of insulin-like growth factor-II via proteinase activity on insulin-like growth factor binding protein 2 in the extracellular matrix (2007), Cancer Sci., 98, 685-691.
    View publication on PubMed
Search for more literature for 3.4.24.23

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular extracellular matrix Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Homo sapiens
Zn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin-like growth factor binding protein-2 + H2O Homo sapiens MMP-7 generates IGF-IIand triggers its matricine action by degradation of the IGF-II/IGFBP-2 complex binding to heparan sulfate proteoglycan in the extracellular matrix, MMP-7 induces phosphorylation of the insulin-like growth factor type-1 receptor in colon cancer cells involving IGF-II but not IGFBP-2, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09237
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-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
 Homo sapiens
-
colonic cancer cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin-like growth factor binding protein-2 + H2O MMP-7 generates IGF-IIand triggers its matricine action by degradation of the IGF-II/IGFBP-2 complex binding to heparan sulfate proteoglycan in the extracellular matrix, MMP-7 induces phosphorylation of the insulin-like growth factor type-1 receptor in colon cancer cells involving IGF-II but not IGFBP-2, overview Homo sapiens ?
-
 ?
insulin-like growth factor binding protein-2 + H2O degradation, three distinct cleavage sites Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-7
-
 Homo sapiens
MMP-7
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens