Literature summary for 3.4.24.23 extracted from

Mochizuki, S.; Shimoda, M.; Shiomi, T.; Fujii, Y.; Okada, Y.
ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3 (2004), Biochem. Biophys. Res. Commun., 315, 79-84.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1,10-phenanthroline	-	Homo sapiens
EDTA	-	Homo sapiens
KB-R7785	-	Homo sapiens
TIMP-3	tissue inhibitor of metalloproteinases-3	Homo sapiens
TIMP-4	tissue inhibitor of metalloproteinases-4	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
CaR-1 cell	rectal carcinoma cell	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
proADAM28s + H2O	secreted form of a member of a disintegrin and metalloproteinase family. ProADAM28s is processed by enzyme to active 42 and 40 kDa forms lacking the propeptide	Homo sapiens	ADAM28s + propeptide	-	?

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Release 2023.1 (January 2023)